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\u836f\u7269\u5931\u8d25\u7684\u53e6\u4e00\u4e2a\u66f4\u52a0\u4e25\u91cd\u7684\u539f\u56e0\u662f\u4e0e\u5176\u4ed6\u836f\u7269\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u5305\u62ec\u5176\u4ed6\u7684\u5904\u65b9\u836f\u3001\u975e\u5904\u65b9\u836f\u6216\u8005\u751a\u81f3\u662f\u76f8\u5f53\u4e0d\u6613\u76d1\u7ba1\u7684\u8349\u836f\u65b9\u5242\u3002\u5728\u8bd5\u9a8c\u9636\u6bb5\uff0c\u8fd9\u79cd\u60c5\u51b5\u4e5f\u8bb8\u53ef\u4ee5\u63a7\u5236\u3002\u6211\u4eec\u53ef\u5728\u8bd5\u9a8c\u65f6\u4e0d\u63a5\u53d7\u6216\u6392\u9664\u90a3\u4e9b\u6b63\u5728\u670d\u7528\u5176\u4ed6\u836f\u7684\u75c5\u4eba\u3002\u4f46\u662f\uff0c\u4e00\u65e6\u836f\u7269\u4e0a\u5e02\uff0c\u53ef\u4ee5\u670d\u7528\u5b83\u7684\u4eba\u6570\u4f1a\u6025\u5267\u4e0a\u5347\uff0c\u5230\u90a3\u65f6\uff0c\u867d\u7136\u533b\u836f\u516c\u53f8\u5bf9\u8be5\u836f\u4ecd\u5177\u6709\u6cd5\u5f8b\u8d23\u4efb\uff0c\u4f46\u5b83\u5df2\u7ecf\u5931\u53bb\u9009\u62e9\u670d\u836f\u5bf9\u8c61\u7684\u63a7\u5236\u529b\u4e86\u3002\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u662f\u64a4\u56de\u5df1\u7ecf\u6279\u51c6\u3001\u4e0a\u5e02\u53ca\u6210\u529f\u8d62\u5229\u836f\u7269\u7684\u4e00\u4e2a\u6700\u4e3a\u5e38\u89c1\u7684\u539f\u56e0\u3002<\/p><\/blockquote>\n\n\n\n
\u4ee3\u8c22\u95ee\u9898\u3002<\/p>\n\n\n\n
\u4e34\u5e8a\u5019\u9009\u5316\u5408\u7269\u6700\u597d\u62e5\u6709\u6240\u6709\u4ee5\u4e0b\u7279\u5f81\uff1a\uff081\uff09\u5728\u4e34\u5e8a\u5df1\u9a8c\u8bc1\u7684\u9776\u70b9\u4e0a\u8d77\u4f5c\u7528\uff1b\uff082\uff09\u5728\u76f8\u5173\u52a8\u7269\u6a21\u578b\u4e0a\u6709\u6548\uff1b\uff083\uff09\u7ed9\u836f\u7a97\u53e3100x\u4ee5\u4e0a\uff0c\u65e0\u9057\u4f20\u6bd2\u6027\u3001\u65e0\u6025\u6027\u548c\u6162\u6027\u6bd2\u6027\uff1b\uff084\uff09\u5242\u91cf\u548c\u5242\u578b\u5177\u6709\u826f\u597d\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\uff1b\uff085\uff09\u65e0\u836f\u7269\u4ea4\u53c9\u53cd\u5e94\uff0c\u4e14\u6700\u597d\u4e0d\u88ab\u7ec6\u80de\u8272\u7d20P4503A4\u6240\u4ee3\u8c22\uff1b\uff086\uff09\u539f\u6599\u6613\u4e8e\u83b7\u5f97\uff0c\u5408\u6210\u6210\u672c\u5408\u7406\u4f4e\u5ec9\uff1b\uff087\uff09\u6709\u4e00\u4e2a\u5408\u9002\u7684\u201c\u540e\u5907\u201d\u5316\u5408\u7269\uff1b\uff088\uff09\u6210\u4e3a\u5168\u79d1\u533b\u751f\u800c\u975e\u4e13\u79d1\u533b\u751f\u7684\u5904\u65b9\u5907\u9009\uff1b\uff089\uff09\u6709\u7ade\u722d\u4f18\u52bf\uff0c\u6700\u597d\u662f\u540c\u7c7b\u836f\u4e2d\u7684\u7b2c\u4e00\u4e2a\uff0c\u5e76\u8fdb\u5165FDA\u7684\u5feb\u901f\u5ba1\u67e5\uff1b\uff0810\uff09\u76f4\u63a5\u7ade\u722d\u6700\u5c0f\uff08\u9488\u5bf9\u540c\u4e00\u9776\u70b9\u7684\u836f\u7269\u5c11\uff09\uff1b\uff0811\uff09\u95f4\u63a5\u7ade\u4e89\u6700\u5c0f\uff08\u5177\u6709\u540c\u4e00\u6548\u679c\u7684\u836f\u7269\u5c11\uff09\uff1b\uff0812\uff09\u4e13\u5229\u4fdd\u62a4\u4e25\u8857\uff0c\u5bff\u547d\u671f\u957f\uff1b<\/strong><\/p><\/blockquote>\n\n\n\n
\u8fd9\u5341\u4e8c\u70b9\u5e94\u8be5\u662f\u672a\u6765\u7684\u836f\u7269\u6295\u8d44\u62a5\u544a\u4e0a\u8981\u4e00\u4e00\u5206\u6790\u7684\u3002<\/p>\n\n\n\n
\u62e5\u6709\u7279\u6b8a\u6280\u80fd\u7684\u836f\u7269\u5316\u5b66\u5bb6\u662f\u836f\u7269\u53d1\u73b0\u8fc7\u7a0b\u7684\u5173\u952e\u7ec4\u6210\u3002\u6700\u597d\u7684\u836f\u7269\u5316\u5b66\u5bb6\u6709\u5f88\u591a\u53d7\u8bad\u4e8e\u76f8\u5bf9\u5c11\u6570\u7684\u51e0\u4e2a\u5bfc\u5e08\u548c\u6765\u81ea\u4e8e\u66f4\u5c11\u6570\u51e0\u4e2a\u7684\u5b9e\u9a8c\u5ba4\uff0c\u5982\u82cf\u9ece\u4e16\u7684\u745e\u58eb\u8054\u90a6\u5de5\u5b66\u9662(ETH)\u3001\u725b\u6d25\u5927\u5b66\u3001\u54e5\u4f26\u6bd4\u4e9a\u5927\u5b66\u3001\u7ebd\u7ea6\u7684\u65af\u9686-\u51ef\u5fb7\u7433(Sloan-Kettering)\u7814\u7a76\u4e2d\u5fc3\u3001\u54c8\u4f5b\u5927\u5b66\u548c\u5339\u5179\u5821\u5927\u5b66\u3002\u533b\u836f\u4ea7\u4e1a\u7684\u7ecf\u6d4e\u6d3b\u52a8\u89c4\u6a21\u5de8\u5927\uff0c\u800c\u8bad\u7ec3\u836f\u7269\u5316\u5b66\u5bb6\u7684\u5b66\u6821\u5374\u5c48\u6307\u53ef\u6570\u3002\u76f8\u53cd\u5730\uff0c\u6bcf\u6240\u8bbe\u7acb\u4e86\u7406\u5de5\u79d1\u548c\u5316\u5b66\u7cfb\u7684\u5927\u5b66\u90fd\u80fd\u57f9\u517b\u6709\u673a\u5408\u6210\u5316\u5b66\u5bb6\u3002<\/p>
\u4e1a\u5185\u7684\u836f\u7269\u5316\u5b66\u5bb6\u5e74\u590d\u4e00\u5e74\u5730\u56f4\u7ed5\u57fa\u672c\u5316\u5b66\u9aa8\u67b6(Scaffold)\u505a\u7740\u76f8\u5bf9\u8f83\u5c0f\u7684\u6539\u52a8\uff0c\u4e34\u5e8a\u5019\u9009\u836f\u7269\u53ca\u5176\u540e\u5907\u5316\u5408\u7269\u5e38\u5e38\u90fd\u51fa\u81ea\u540c\u4e00\u9aa8\u67b6\u7c7b\u578b\u3002\u4e3a\u4e86\u5f97\u5230\u6839\u672c\u4e0a\u5168\u65b0\u7684\u9aa8\u67b6\uff0c\u4eba\u4eec\u66fe\u7ecf\u6781\u5927\u7684\u4f9d\u8d56\u4e8e\u5929\u7136\u4ea7\u7269\u300220\u4e16\u7eaa\u521d\u53d1\u73b0\u76848~10\u79cd\u9aa8\u67b6\u9891\u9891\u4f7f\u7528\uff0c\u5e76\u4ee3\u8868\u4e86\u6240\u6709\u4e3b\u8981\u836f\u4f01\u7684\u201c\u5386\u53f2\u201d\u5316\u5408\u7269\u5e93\u4e2d\u5927\u90e8\u5206\u5316\u5408\u7269\u7684\u57fa\u672c\u7ed3\u6784(Box11.1)\u3002<\/p>
\u516c\u53f8\u6700\u5b9d\u8d35\u7684\u8d44\u6e90\u4e4b\u4e00\u5c31\u662f\u836f\u7269\u5316\u5b66\u5bb6\u3002\u4ed6\u4eec\u59cb\u7ec8\u662f\u6bcf\u4e00\u9879\u4e34\u5e8a\u524d\u7814\u7a76\u7684\u5173\u952e\u70b9\u548c\u74f6\u9888\uff0c\u8fd9\u53ea\u5728\u5c11\u6570\u7684\u751f\u7269\u5236\u54c1\u3001\u6cbb\u7597\u6027\u6297\u4f53\u53ca\u91cd\u7ec4\u86cb\u767d\u836f\u7269\u7684\u5f00\u53d1\u4e2d\u662f\u4f8b\u5916\u3002\u73b0\u5b9e\u4e2d\u7684\u8bc1\u636e\u5c31\u662f\uff0c\u516c\u53f8\u5408\u5e76\u540e\u6700\u5b89\u5168\u7684\u5c97\u4f4d\u5c31\u662f\u836f\u7269\u5316\u5b66\u5bb6\u3002\u4ece\u4e8b\u4e34\u5e8a\u524d\u7814\u7a76\u7684\u751f\u7269\u5b66\u5bb6\u5bf9\u51b3\u7b56\u7684\u5f71\u54cd\u6700\u5c0f\u3002<\/p><\/blockquote>\n\n\n\n
\u627e\u5230\u5173\u952e\u4eba\uff1a\u836f\u7269\u5316\u5b66\u5bb6\u3002<\/p>\n\n\n\n
\u7ecf\u8fc7\u6240\u6709\u4e34\u5e8a\u524d\u9636\u6bb5\u7684\u52aa\u529b\uff0c\u5019\u9009\u5316\u5408\u7269\u548c\u9776\u70b9\u5fc5\u987b\u5728\u4eba\u4f53\u5185\u8fdb\u884c\u9a8c\u8bc1\u3002\u533b\u836f\u516c\u53f8\u5411FDA\u7533\u8bf7\u4e00\u4e2a\u65b0\u836f\u8bd5\u9a8c(IND)\u8bb8\u53ef\uff0c\u4ee5\u4fbf\u5728\u201c\u4eba\u4f53\u5185\u201d\u5f00\u5c55\u7814\u7a76\u3002\u6bcf\u4e2a\u5019\u9009\u5316\u5408\u7269\u90fd\u5fc5\u987b\u7ecf\u4f53\u5185\u5b9e\u9a8c\u8fdb\u884c\u201c\u539f\u7406\u9a8c\u8bc1(PoP)\u201d\u3002\u5728\u8fc7\u53bb\u76845\u5e74\u95f4\u5927\u578b\u533b\u836f\u516c\u53f8\u7684\u4e34\u5e8a\u8bd5\u9a8c\u670930%\u4ee5\u4e0a\u662f\u539f\u7406\u9a8c\u8bc1\u6027\u8d28\u7684\u3002\u533b\u836f\u516c\u53f8\u9700\u8981\u5728\u4eba\u4f53\u5185\u539f\u7406\u9a8c\u8bc1\u5b9e\u9a8c\u4e0a\u82b1\u8d391000\u4e07~3000\u4e07\u7f8e\u5143\uff0c\u901a\u5e38\u662f\u201c\u5e76\u4e0d\u5b8c\u7f8e\u201d\u4f46\u5b89\u5168\u65e0\u5bb3\u3001\u663e\u7136\u4e0d\u4f1a\u6210\u836f\u7684\u5316\u5408\u7269\u3002<\/p><\/blockquote>\n\n\n\n
\u5c0f\u5fc3\u8fd9\u4e2a\u5751\uff0c\u539f\u7406\u9a8c\u8bc1\u540e\u4e0d\u63a8\u8fdb\u662f\u5927\u516c\u53f8\u7684\u7279\u6743\uff0cbiotech\u516c\u53f8\u4f1a\u6b7b\u4eba\u7684\u3002<\/p>\n\n\n\n
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