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class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>\u4ece1991\u5e74\u53d1\u73b0\u75c5\u6bd2\u6837\u9897\u7c92\u4ee5\u6765\uff0c\u5728\u7814\u53d1HPV\u75ab\u82d7\u7684\u7ade\u4e89\u4e2d\u6d8c\u73b0\u51fa\u4e24\u4f4d\u5173\u952e\u9009\u624b\u3002\u9a6c\u91cc\u5170\u5dde\u76d6\u745f\u65af\u5821\u4e00\u5bb6\u540d\u53ebMedImmune\u7684\u5c0f\u516c\u53f8\u5229\u7528\u75c5\u6bd2\u6837\u9897\u7c92\u6280\u672f\u5f00\u53d1\u4e86\u4e00\u79cd\u75ab\u82d7\uff0c\u5176\u4e2d\u5305\u542b\u4e0e\u5bfc\u81f4\u751f\u6b96\u5668\u75b1\u75b9\u7684\u75c5\u6bd2\uff08HPV\u20136\uff09\u548c\u5bfc\u81f4\u5bab\u9888\u764c\u7684\u75c5\u6bd2\uff08HPV\u201311\u3001HPV\u201316\u548cHPV\u201318\uff09\u6709\u5173\u7684\u4e3b\u8981\u7c7b\u578b\u7684HPV\u3002\u8fd9\u5bb6\u516c\u53f8\u7814\u53d1\u7684\u75ab\u82d7\u5728\u52a8\u7269\u5b9e\u9a8c\u548c\u4e8c\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u90fd\u8868\u73b0\u51fa\u4e86\u663e\u8457\u7684\u4fdd\u62a4\u4f5c\u7528\uff0c\u4ece\u800c\u8bc1\u5b9e\u4e86\u75ab\u82d7\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u9762\u5bf9\u4e3a\u83b7\u5f97FDA\u8bb8\u53ef\u800c\u8981\u8fdb\u884c\u7684\u5927\u89c4\u6a21\u8bd5\u9a8c\uff0cMedImmune\u516c\u53f8\u610f\u8bc6\u5230\u81ea\u5df1\u6ca1\u6709\u8fdb\u884c\u4e09\u671f\u4e34\u5e8a\u7814\u7a76\u7684\u8d44\u6e90\uff0c\u4e8e\u662f\u9009\u62e9\u4e0e\u5927\u578b\u5236\u836f\u516c\u53f8\u845b\u5170\u7d20\u53f2\u514b\u5408\u4f5c\uff0c\u4ee5\u5b8c\u6210\u4ea7\u54c1\u7684\u7814\u53d1\u6d41\u7a0b\u3002<\/p>\n<\/blockquote>\n\n\n\n<p>HPV-6\u5c45\u7136\u6709\u7279\u6b8a\u4f5c\u7528\uff0c\u51b7\u77e5\u8bc6\uff0c\u96be\u602a\u4e5f\u8ba9\u7537\u751f\u6253\u3002MedImmune\u8fd9\u5bb6\u516c\u53f8\u4e0d\u53ea\u75ab\u82d7\u505a\u7684\u597d\uff0c\u4e5f\u662f\u5355\u6297\u5c4a\u7684\u5927\u73a9\u5bb6\u3002<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>\u201cBCG\u662f\u201cBacillus Calmette-Guerin\u201d\uff08\u5361\u5c14\u6885\u7279\u2014\u4ecb\u6717\u6746\u83cc\uff09\u7684\u7f29\u5199\uff0c\u662f\u4ee5\u53d1\u73b0\u4e86\u7ed3\u6838\u75c5\u81f4\u75c5\u83cc\u7684\u4e24\u4f4d\u6cd5\u56fd\u79d1\u5b66\u5bb6\u7684\u540d\u5b57\u547d\u540d\u7684\u3002\u4ece1908\u5e74\u8d77\uff0c\u8fd9\u4e09\u4f4d\u7814\u7a76\u8005\u5c31\u5728\u80c6\u6c41\u548c\u9a6c\u94c3\u85af\u7247\u7684\u6df7\u5408\u7269\u4e2d\u8fde\u7eed\u57f9\u517b\u8fd9\u79cd\u65b0\u7684\u7ec6\u83cc\uff0c\u5f97\u5230\u4e86\u4e00\u79cd\u6bd2\u6027\u6bd4\u91ce\u751f\u83cc\u682a\u5f31\u7684\u7ed3\u6838\u6746\u83cc\u53d8\u79cd\u3002\u8fd9\u79cd\u6bd2\u6027\u51cf\u5f31\u7684BCG\u53d8\u79cd\u4ecd\u7136\u80fd\u591f\u5f15\u8d77\u76f8\u5f53\u4e25\u91cd\u7684\u611f\u67d3\uff0c\u901a\u8fc7\u89e6\u53d1\u9ad8\u70e7\u548c\u5728\u6ce8\u5c04\u90e8\u4f4d\u7559\u4e0b\u75a4\u75d5\u7b49\u5267\u70c8\u7684\u514d\u75ab\u5e94\u7b54\u8d4b\u4e88\u673a\u4f53\u514d\u75ab\u529b\u3002\u4e0d\u523010\u5e74\uff0c\u4ed6\u5c31\u53d1\u73b0\u4e86\u7531\u5361\u4ecb\u82d7\u8bf1\u5bfc\u4ea7\u751f\u7684\u4e00\u79cd\u80fd\u6740\u6b7b\u764c\u7ec6\u80de\u7684\u795e\u5947\u7269\u8d28\uff0c\u4ece\u800c\u63a8\u52a8\u4e86\u8fd9\u4e00\u9886\u57df\u7684\u53d1\u5c55\u3002\u4e0d\u6070\u5f53\u5730\u5957\u53e5\u8def\u6613\u00b7\u5df4\u65af\u5fb7\u8bf4\u8fc7\u7684\u8bdd\uff0c\u8fd9\u9879\u7a81\u7834\u662f\u673a\u9047\u4e0e\u6709\u51c6\u5907\u7684\u5934\u8111\u5171\u540c\u9020\u5c31\u7684\u3002\u57281975\u5e74\u7684\u7814\u7a76\u4e2d\uff0c\u5965\u5c14\u5fb7\u5206\u79bb\u51fa\u4e00\u79cd\u7531\u5c0f\u9f20\u514d\u75ab\u7ec6\u80de\u4ea7\u751f\u7684\u201c\u56e0\u5b50\u201d\uff0c\u5b83\u80fd\u4ee5\u76f8\u5f53\u6709\u653b\u51fb\u6027\u7684\u65b9\u5f0f\u6709\u9009\u62e9\u5730\u6740\u6b7b\u764c\u7ec6\u80de\u3002\u8fd9\u79cd\u7269\u8d28\u88ab\u5965\u5c14\u5fb7\u548c\u4ed6\u7684\u5408\u4f5c\u4f19\u4f34\u79f0\u4e3a\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\uff08\u7b80\u79f0TNF\uff09\u3002<\/p>\n<\/blockquote>\n\n\n\n<p>\u75c5\u6bd2\u611f\u67d3\u3001\u6fc0\u53d1\u514d\u75ab\uff0c\u53d1\u73b0\u4e86\u771f\u6b63\u8d77\u4f5c\u7528\u7684TNF\uff0c\u795e\u5947\u7684\u6548\u679c\u3002<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u7eaf\u5316TNF\u7684\u6548\u529b\u548c\u5371\u9669\u6027\u88ab\u8bc1\u660e\u6bd4\u5361\u4ecb\u82d7\u8981\u5927\u5f97\u591a\uff0c\u4f1a\u5f15\u8d77\u65e0\u6cd5\u63a7\u5236\u7684\u53d1\u70ed\u548c\u8fc7\u5ea6\u7684\u514d\u75ab\u5e94\u7b54\u3002\u7528TNF\u6cbb\u7597\u5bfc\u81f4\u7684\u4e25\u91cd\u708e\u75c7\u5c3d\u7ba1\u4e0e\u8bb8\u591a\u5371\u9669\u7684\u81ea\u8eab\u514d\u75ab\u75c5\u7684\u6bd2\u6027\u6548\u5e94\u975e\u5e38\u76f8\u4f3c\uff0c\u4f46\u53d1\u5c55\u7684\u901f\u5ea6\u66f4\u5feb\uff0c\u5371\u5bb3\u4e5f\u66f4\u5927\u3002\u6240\u4ee5\uff0c\u7814\u7a76\u4eba\u5458\u5f88\u5feb\u5c31\u56e0TNF\u4e0d\u4f1a\u6210\u4e3a\u4eba\u7c7b\u6025\u9700\u836f\u7269\u7684\u4e8b\u5b9e\u5931\u53bb\u4e86\u4fe1\u5fc3\u3002<\/p>\n<\/blockquote>\n\n\n\n<p>\u4eca\u5929\u7684TNF\u6297\u4f53\u5df2\u7ecf\u6210\u4e3a\u6807\u51c6\u7684\u4e00\u7ebf\u7597\u6cd5\uff0c\u963f\u8fbe\u6728\u5355\u6297\u96c4\u8e1e\u5168\u7403\u836f\u738b\u591a\u5e74\u3002\u5f53\u5e74\u4e5f\u53d7\u56f0\u4e8e\u6bd2\u6027\u3002\u6240\u4ee5\u6bd2\u6027\u7684\u95ee\u9898\u51e0\u4e4e\u4e00\u5b9a\u662f\u53ef\u89e3\u7684\uff0c\u7597\u6548\u5219\u4e0d\u4e00\u5b9a\uff0c\u6ca1\u6709\u5c31\u662f\u6ca1\u6709\u3002\u53d1\u73b0\u673a\u5236\u7684\u5173\u952e\u8fd8\u662f\u53d1\u73b0\u7597\u6548\uff0c\u6bd2\u6027\u662f\u53ef\u4ee5\u6301\u7eed\u4f18\u5316\u7684\u3002<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>\u7ecf\u8fc7\u8bba\u8bc1\uff0c\u4ed6\u4eec\u53d1\u73b0\u5e2e\u52a9B\u7ec6\u80de\u4ea7\u751f\u6297\u4f53\u9700\u8981\u5e26\u6709Ly\u20131\u6297\u539f\u7684\u7ec6\u80de\uff0c\u800c\u8868\u8fbeLy\u20132\u7684\u7ec6\u80de\u5219\u8d1f\u8d23\u76f4\u63a5\u6740\u6b7b\u5916\u6765\u7ec6\u80de\u3002\u591a\u5e74\u540e\uff0c\u6700\u521d\u88ab\u786e\u5b9a\u4e3aLy\u20131\u7684\u5206\u5b50\u88ab\u91cd\u65b0\u547d\u540d\u4e3aCD4\uff0c\u800cLy\u20132\u5219\u88ab\u79f0\u4e3aCD8\u3002\u6211\u4eec\u5df2\u7ecf\u770b\u5230\uff0c\u7531\u4e8e\u827e\u6ecb\u75c5\u5927\u6d41\u884c\uff0c\u8bb8\u591a\u4e0d\u662f\u79d1\u5b66\u5bb6\u7684\u4eba\u4e5f\u5df2\u7ecf\u77e5\u9053\uff0cCD4\u2013T\u7ec6\u80de\u5728\u5e2e\u52a9\u6574\u4e2a\u514d\u75ab\u7cfb\u7edf\u6b63\u5e38\u8fd0\u8f6c\u65b9\u9762\u8d77\u5230\u4e86\u5173\u952e\u4f5c\u7528\uff0c\u800c\u4e14T\u7ec6\u80de\u8ba1\u6570\u4f4e\u5bfc\u81f4\u4e86\u5f88\u591a\u827e\u6ecb\u75c5\u60a3\u8005\u6b7b\u4ea1\u3002CD4\u7ec6\u80de\u4e5f\u88ab\u79f0\u4e3a\u201c\u8f85\u52a9\u6027T\u7ec6\u80de\u201d\uff0c\u800cCD8\u2013T\u7ec6\u80de\u5219\u6709\u4e00\u4e2a\u66f4\u5371\u9669\u7684\u540d\u5b57\uff1a\u201c\u6740\u4f24\u6027T\u7ec6\u80de\u201d\u3002<\/p>\n<\/blockquote>\n\n\n\n<p>CD\u7cfb\u5217\uff0cCD4\u3001CD8\uff0c\u4eca\u5929\u7684CD8\u4f9d\u7136\u662f\u4e0d\u9519\u7684\u9776\u70b9\u3002<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>\u8fd9\u6b21\u5931\u8d25\u7684\u6559\u8bad\u4e5f\u7ed9\u7eb3\u5fb7\u52d2\u4e0a\u4e86\u5b9d\u8d35\u7684\u4e00\u8bfe\uff1a\u5728\u80bf\u7624\u4e0d\u65ad\u64ad\u6563\u7269\u8d28\u7684\u60c5\u51b5\u4e0b\uff0c\u6297\u4f53\u51e0\u4e4e\u4e0d\u53ef\u80fd\u5bf9\u764c\u75c7\u4ea7\u751f\u7597\u6548\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u7269\u8d28\u4f1a\u4f5c\u4e3a\u8bf1\u9975\uff0c\u5728\u6297\u4f53\u63a5\u89e6\u5230\u80bf\u7624\u7ec6\u80de\u4e4b\u524d\u5c31\u4e0e\u524d\u8005\u7ed3\u5408\u5728\u4e00\u8d77\u3002\u5173\u952e\u95ee\u9898\u662f\u8981\u5728\u80bf\u7624\u4e0a\u9762\u786e\u5b9a\u4e00\u4e2a\u9776\u70b9\uff0c\u8fd9\u4e2a\u9776\u70b9\u4e0d\u80fd\u88ab\u6563\u64ad\u5230\u8840\u6db2\u4e2d\u3002\u540e\u6765\u6709\u8bc1\u636e\u8868\u660e\uff0c\u51fa\u8272\u7684\u674e\u00b7\u7eb3\u5fb7\u52d2\u5df2\u7ecf\u8fd9\u6837\u505a\u4e86\u3002<\/p>\n<\/blockquote>\n\n\n\n<p>\u4e0d\u80fd\u88ab\u764c\u7ec6\u80de\u6563\u64ad\u7684\u9776\u70b9\u624d\u662f\u6709\u6548\u7684\u9776\u70b9\uff0c\u7279\u5f02\u6027\u9776\u70b9\u3002\u6362\u8a00\u4e4b\u8840\u6db2\u4e2d\u5bb9\u6613\u6d4b\u51fa\u6765\u7684\u86cb\u767d\uff0c\u591a\u534a\u5c31\u662f\u5bb9\u6613\u6563\u64ad\u7684\u8fd9\u7c7b\u4e86\uff0c\u867d\u7136\u4e0d\u80fd\u4f5c\u4e3a\u6cbb\u7597\u9776\u70b9\uff0c\u76d1\u6d4b\u7597\u6548\u662f\u4e0d\u9519\u7684\u3002<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>\u5c3d\u7ba1\u627e\u5230\u4e86\u53e6\u59163\u4e2aB\u7ec6\u80de\u7279\u5f02\u6027\u9776\u70b9\uff08\u73b0\u5728\u88ab\u79f0\u4e3aCD19\u3001CD21\u548cCD22\uff09\uff0c\u4f46B1\u5206\u5b50\u4ecd\u7136\u662f\u9776\u5411\u6cbb\u7597B\u7ec6\u80de\u764c\u75c7\u7684\u6700\u4f73\u9009\u62e9\u3002\u867d\u7136B1\u6297\u4f53\u7684\u5b9e\u9a8c\u5ba4\u7ed3\u679c\u975e\u5e38\u7406\u60f3\uff0c\u4f46\u66f4\u5927\u7684\u6311\u6218\u662f\u8981\u786e\u5b9a\u4e0eB1\u6297\u4f53\u7ed3\u5408\u7684\u7a76\u7adf\u662f\u8c01\u3002\u7eb3\u5fb7\u52d2\u548c\u65bd\u6d1b\u65af\u66fc\u7684\u5176\u4ed6\u5408\u4f5c\u4f19\u4f34\u4e3a\u627e\u5230B1\u9776\u70b9\u63d0\u4f9b\u4e86\u5fc5\u8981\u7684\u86cb\u767d\u8d28\u751f\u7269\u5316\u5b66\u77e5\u8bc6\u30021983\u5e74\uff0c\u7531B1\u6297\u4f53\u8bc6\u522b\u7684\u86cb\u767d\u8d28\u5f00\u59cb\u88ab\u8868\u5f81\uff1b\u5230\u4e861985\u5e74\uff0cB1\u86cb\u767d\u8d28\u88ab\u53d1\u73b0\uff0c\u4e0d\u4e45\u540e\u5c31\u88ab\u91cd\u65b0\u547d\u540d\u4e3aCD20\u3002<\/p>\n<\/blockquote>\n\n\n\n<p>CD19\u3001CD20\u7684\u6e90\u8fdc\u3002CD20\u6700\u4f18\uff0cCD19\u6b21\u4e4b\u3002\u4f46CD20\u8010\u836f\u4e4b\u540e\uff0cCD19\u5c31\u53c8\u6210\u4e3a\u9009\u9879\u4e86\u3002<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>1978\u5e749\u670818\u65e5\uff0c\u4e00\u5bb6\u751f\u7269\u6280\u672f\u516c\u53f8\u5728\u51b7\u6e05\u7684\u5723\u8fed\u6208\u90ca\u533a\u4e00\u4e2a\u53eb\u62c9\u8377\u4e9a\u7684\u5730\u65b9\u6210\u7acb\u4e86\u3002\u8fd9\u5bb6\u65b0\u516c\u53f8\u53eb\u4f5c\u201cHybritech\u201d\u2014\u2014\u4f53\u73b0\u4e86\u201ctechnology\u201d\uff08\u6280\u672f\uff09\u4e0e\u201chybridomas\u201d\uff08\u6742\u4ea4\u7624\u7ec6\u80de\uff09\u7684\u7ed3\u5408\uff0c\u6742\u4ea4\u7624\u7ec6\u80de\u662f\u4e00\u79cd\u72ec\u7279\u7684\u7ecf\u8fc7\u6539\u9020\u7684\u80bf\u7624\u7ec6\u80de\uff0c\u80fd\u591f\u4ea7\u751f\u5355\u514b\u9686\u6297\u4f53\u3002\u5728\u62c9\u8377\u4e9a\uff0c\u4ee5Hybritech\u4e3a\u6838\u5fc3\u5f62\u6210\u4e86\u4e00\u4e2a\u84ec\u52c3\u53d1\u5c55\u7684\u751f\u7269\u6280\u672f\u793e\u533a\uff0c\u5149\u662f\u6765\u81eaHybritech\u7684\u521b\u4e1a\u8005\u5c31\u6210\u7acb\u4e86\u81f3\u5c1140\u5bb6\u540e\u7ee7\u7684\u751f\u7269\u6280\u672f\u7ec4\u7ec7\u3002Hybritech\u53ca\u5176\u62e5\u6709\u7684\u5355\u514b\u9686\u6297\u4f53\u6280\u672f\u83b7\u5f97\u4e86\u5de8\u5927\u7684\u6210\u529f\uff0c1985\u5e749\u6708\uff0c\u5728\u516c\u53f8\u6210\u7acb7\u5e74\u96f61\u5929\u7684\u65f6\u5019\uff0c\u793c\u6765\u516c\u53f8\u4ee53\u4ebf\u7f8e\u5143\u7684\u4ef7\u683c\u6536\u8d2d\u4e86Hybritech\uff0c\u662f\u51ef\u9e4f\u534e\u76c8\u539f\u59cb\u6295\u8d44\u76841000\u500d\u3002<\/p>\n<\/blockquote>\n\n\n\n<p>KPCB\u7684\u751f\u7269\u533b\u836f\u6295\u8d44\u539f\u6765\u4e0d\u662f\u4ecegentech\u5f00\u59cb\uff0c\u800c\u662f\u8fd9\u5bb6Hybritech\u3002<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>1992\u5e7412\u6708\uff0cIDEC\u5411FDA\u63d0\u4ea4\u4e86\u542f\u52a8IDEC\u2013C2B8\u4e34\u5e8a\u8bd5\u9a8c\u6240\u9700\u7684\u6587\u4ef6\u3002\u8fd9\u9879\u7814\u7a76\u4e8e1993\u5e742\u6708\u5f00\u59cb\uff0c\u662f\u5bf9\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u60a3\u8005\u8fdb\u884c\u7684\u4e00\u6b21\u5355\u5242\u91cf\u7814\u7a76\u3002\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u662f\u4e00\u79cdB\u7ec6\u80de\u764c\u75c7\uff0c\u5176\u6076\u6027\u7ec6\u80de\u8868\u9762\u6709\u5927\u91cf\u53ef\u4f5c\u4e3a\u6297\u4f53\u76ee\u6807\u7684CD20\u3002\u5728\u63a5\u53d7\u5355\u5242\u91cfIDEC\u2013C2B8\u7684\u6cbb\u7597\u540e\uff0c\u7ed3\u679c\u975e\u5e38\u60ca\u4eba\uff1a15\u540d\u63a5\u53d7\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u67096\u4eba\u663e\u793a\u51fa\u80bf\u7624\u840e\u7f29\u7684\u8ff9\u8c61\u3002\u52301994\u5e7410\u6708\u53d1\u8868\u8bd5\u9a8c\u7ed3\u679c\u7684\u65f6\u5019\uff0c\u4e00\u5411\u654f\u9510\u3001\u4f4e\u8c03\u800c\u6709\u7d27\u8feb\u611f\u7684IDEC\u5df2\u7ecf\u5b8c\u6210\u4e86\u4e34\u5e8a\u4e8c\u671f\u8bd5\u9a8c\uff0c\u4ece\u800c\u8bc1\u5b9e\u4e86\u4ea7\u54c1\u7684\u6709\u6548\u6027\u3002\u8fd9\u4e9b\u7ed3\u679c\u5bf9\u786e\u5b9a\u5173\u952e\u7684\u4e34\u5e8a\u4e09\u671f\u7814\u7a76\u8981\u4f7f\u7528\u7684\u5242\u91cf\uff0c\u4ece\u800c\u83b7\u5f97FDA\u6279\u51c6\u4e0a\u5e02\u6709\u5f88\u91cd\u8981\u7684\u610f\u4e49\u3002\u8fd9\u9879\u5173\u952e\u7684\u4e34\u5e8a\u4e09\u671f\u7814\u7a76\u5df2\u7ecf\u57fa\u672c\u8bbe\u8ba1\u5b8c\u6210\uff08\u901a\u5e38\u9700\u8981\u6570\u6708\u6216\u6570\u5e74\u7684\u65f6\u95f4\uff09\uff0c\u5e76\u8ba1\u5212\u4e8e1995\u5e743\u6708\u542f\u52a8\u3002IDEC\u56e2\u961f\u4fdd\u6301\u7740\u8fd9\u79cd\u4e0d\u505c\u6b47\u7684\u8282\u594f\uff0c\u5728\u4e24\u5e74\u5185\u4e0d\u4ec5\u9ad8\u6548\u5730\u5b8c\u6210\u4e86\u4e34\u5e8a\u4e09\u671f\u8bd5\u9a8c\uff0c\u8fd8\u63d0\u4ea4\u4e86FDA\u6240\u9700\u7684\u5168\u90e8\u6587\u4ef6\uff08\u6709\u6210\u5343\u4e0a\u4e07\u9875\uff09\u30021997\u5e7411\u6708\uff0cFDA\u5ba1\u67e5\u4e86\u8bd5\u9a8c\u7ed3\u679c\u5e76\u6279\u51c6\u4e86\u8fd9\u79cd\u73b0\u5728\u88ab\u79f0\u4e3a\u201c\u7f8e\u7f57\u534e\u00ae\u201d\uff08\u5229\u59a5\u6614\u5355\u6297\uff09\u7684\u4ea7\u54c1\u3002<\/p>\n<\/blockquote>\n\n\n\n<p>\u8fd9\u4e48\u6709\u6548\u7684\u4ea7\u54c1\u8fd8\u662f\u8fc7\u4e86\u4e09\u671f\u624d\u7533\u8bf7NDA\uff0c\u800c\u4e0d\u662f\u4e8c\u671f\u7533\u8bf7\u3002<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow 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class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>\u8003\u8651\u5230\u764c\u75c7\u7684\u9ad8\u53d1\u75c5\u7387\uff0c\u6709\u4eba\u731c\u6d4b\u764c\u7ec6\u80de\u4f1a\u4e3b\u52a8\u4e89\u53d6\u5c3d\u53ef\u80fd\u5730\u8fdc\u79bbT\u7ec6\u80de\uff08\u4eba\u4f53\u5185\u7684\u201c\u6cbb\u5b89\u5b98\u201d\uff0c\u8d1f\u8d23\u5bfb\u627e\u5e76\u6467\u6bc1\u764c\u7ec6\u80de\uff09\u3002\u4f46\u4e8b\u5b9e\u6070\u6070\u76f8\u53cd\u3002\u901a\u5e38\uff0c\u80bf\u7624\u53ef\u80fd\u51e0\u4e4e\u662f\u6d78\u6ce1\u5728T\u7ec6\u80de\u5f53\u4e2d\uff0c\u4f46\u5173\u952e\u5728\u4e8e\u8fd9\u4e9bT\u7ec6\u80de\u8981\u4e48\u5df2\u7ecf\u5931\u53bb\u4e86\u6740\u6b7b\u764c\u7ec6\u80de\u7684\u80fd\u529b\uff0c\u8981\u4e48\u53ea\u80fd\u8bc6\u522b\u9664\u80bf\u7624\u4ee5\u5916\u7684\u5176\u4ed6\u4e1c\u897f\u3002<\/p>\n<\/blockquote>\n\n\n\n<p>\u8fd9\u5c31\u662f\u6709\u8da3\u4e4b\u5904\uff0cT\u7ec6\u80de\u5b9e\u9645\u5728\u5e2e\u52a9\u80bf\u7624\u751f\u957f\uff0c\u80fd\u6fc0\u6d3bT\u7ec6\u80de\u540c\u65f6\u63a7\u5236\u6bd2\u6027\u5c31\u4f1a\u6709\u5de8\u5927\u7684\u6cbb\u7597\u6548\u679c\u51fa\u6765\u3002<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u8fd9\u79cd\u5206\u5b50\u7684\u8868\u73b0\u4e5f\u5f88\u795e\u5947\u3002\u4e8b\u5b9e\u4e0a\uff0c\u5b83\u7684\u6548\u679c\u8fc7\u4e8e\u6709\u6548\u3002\u6839\u636e\u8bbe\u8ba1\u9636\u6bb5\u7684\u6784\u60f3\uff0cMT\u2013103\u4f1a\u6307\u6d3e\u4e00\u79cd\u514d\u75ab\u7ec6\u80de\uff08T\u7ec6\u80de\uff09\u53bb\u6740\u6b7b\u53e6\u4e00\u79cd\u7ec6\u80de\uff08\u6076\u6027B\u7ec6\u80de\uff09\u3002\u5f88\u591aT\u7ec6\u80de\u4f1a\u88ab\u6fc0\u6d3b\uff0c\u4ece\u800c\u4ea7\u751f\u4e00\u79cd\u53eb\u4f5c\u201c\u7ec6\u80de\u56e0\u5b50\u201d\u7684\u526f\u4ea7\u54c1\uff0c\u8fd9\u4e9b\u5206\u5b50\u7684\u4f5c\u7528\u662f\u5e2e\u52a9\u63d0\u9192\u8eab\u4f53\u5c0f\u5fc3\u5916\u6765\u7684\u5165\u4fb5\u8005\u3002\u8fd9\u4e9b\u7ec6\u80de\u56e0\u5b50\u4ea7\u751f\u7684\u4e00\u4e2a\u5f71\u54cd\u662f\u4f7f\u8840\u7ba1\u677e\u5f1b\uff0c\u4ece\u800c\u5bfc\u81f4\u8840\u6db2\u4e2d\u7684\u514d\u75ab\u7ec6\u80de\u8fdb\u5165\u7ec4\u7ec7\u3002\u8fd9\u4e9b\u884c\u4e3a\u89e3\u91ca\u4e86\u4e3a\u4ec0\u4e48\u4f24\u53e3\u4f1a\u7531\u4e8e\u8fc7\u591a\u7684\u7ec6\u80de\u548c\u4f53\u6db2\u800c\u8fc5\u901f\u80bf\u80c0\u3002\u5728\u5927\u91cf\u7684\u7ec6\u80de\u56e0\u5b50\u653e\u5927\u548c\u52a0\u901f\u8fd9\u4e00\u8fc7\u7a0b\u7684\u60c5\u51b5\u4e0b\uff0c\u8840\u538b\u4f1a\u663e\u8457\u964d\u4f4e\uff0c\u80be\u810f\u7b49\u5173\u952e\u5668\u5b98\u5f88\u5feb\u4f1a\u7f3a\u6c27\uff0c\u672c\u8d28\u4e0a\u76f8\u5f53\u4e8e\u4ece\u5185\u90e8\u4f7f\u60a3\u8005\u7a92\u606f\u3002\u66f4\u7cdf\u7cd5\u7684\u662f\uff0cMT-103\u7684\u9776\u70b9\u662f\u53e6\u4e00\u79cd\u6dcb\u5df4\u7ec6\u80de\uff0c\u800c\u8fd9\u79cd\u6dcb\u5df4\u7ec6\u80de\u5728\u88ab\u6740\u6b7b\u7684\u8fc7\u7a0b\u4e2d\u4e5f\u4f1a\u91ca\u653e\u81ea\u5df1\u7684\u7ec6\u80de\u56e0\u5b50\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u9884\u6d4b\u5e76\u4e14\u53d1\u73b0\uff0cMT\u2013103\u6cbb\u7597\u4f1a\u8fc5\u901f\u52a0\u91cd\u7ec6\u80de\u56e0\u5b50\u5f15\u8d77\u7684\u75c7\u72b6\uff0c\u5176\u4e25\u91cd\u7a0b\u5ea6\u5c06\u4ec5\u6b21\u4e8e\u6700\u4e25\u91cd\u7684\u6d41\u611f\u75c5\u6bd2\u611f\u67d3\u3002\u201c\u4e8b\u5b9e\u4e0a\uff0c\u5982\u679c\u4e0d\u52a0\u4ee5\u8c03\u8282\uff0cMT\u2013103\u53ef\u80fd\u4f1a\u5f15\u53d1\u6bd4\u764c\u75c7\u672c\u8eab\u66f4\u52a0\u81f4\u547d\u7684\u7ec6\u80de\u56e0\u5b50\u98ce\u66b4\u3002\u6700\u7ec8\uff0cMT\u2013103\u9879\u76ee\u83b7\u5f97\u4e86FDA\u7684\u6279\u51c6\uff0c\u5e76\u4f5c\u4e3a\u535a\u7eb3\u5410\u5355\u6297\uff08\u5546\u54c1\u540d\u79f0\uff1aBlincyto\u00ae\uff09\u8fdb\u884c\u9500\u552e\u3002\u7136\u800c\uff0c\u8fd9\u6b3e\u4ea7\u54c1\u7684\u4f9b\u5e94\u5546\u6700\u7ec8\u53d8\u6210\u4e86MedImmune\u7684\u7ade\u4e89\u5bf9\u624b\u5b89\u8fdb\u516c\u53f8\u3002\u5bfc\u81f4\u8fd9\u4e00\u53d8\u6545\u7684\u539f\u56e0\u5f88\u590d\u6742\uff0c\u6211\u81f3\u4eca\u5bf9\u6b64\u611f\u5230\u56f0\u60d1\uff0c\u4e0d\u8fc7MedImmune\u4e4b\u6240\u4ee5\u9009\u62e9\u653e\u5f03MT\u2013103\uff0c\u662f\u56e0\u4e3a\u62c5\u5fc3\u8fd9\u79cd\u836f\u7269\u5728\u7ed9\u836f\u65f6\u5c06\u9700\u8981\u4e00\u4e2a\u201c\u80cc\u5305\u201d\u3002\u201c\u80cc\u5305\u201d\u662f\u4e00\u4e2a\u8d2c\u4e49\u8bcd\uff0c\u6307\u7684\u662f\u53c8\u957f\u53c8\u6162\u7684\u7ed9\u836f\u8fc7\u7a0b\uff0c\u5c06\u9700\u8981\u60a3\u8005\u5728\u957f\u8fbe\u4e24\u5468\u7684\u65f6\u95f4\u91cc\u968f\u8eab\u643a\u5e26\u9759\u8109\u6ce8\u5c04\u7ba1\u3002\u5c3d\u7ba1\u8fd9\u79cd\u88c5\u7f6e\u5df2\u7ecf\u5f88\u6210\u719f\u5e76\u4e14\u88ab\u7528\u4e8e\u6cbb\u7597\u5176\u4ed6\u75be\u75c5\uff0c\u4f46MedImmune\u7684\u8425\u9500\u56e2\u961f\u5e0c\u671b\u5b9e\u73b0\u5355\u6b21\u6ce8\u5c04\uff0c\u8fd8\u8bf4\u60a3\u8005\u4f1a\u56e0\u4e3a\u8981\u5728\u534a\u4e2a\u6708\u7684\u65f6\u95f4\u91cc\u62d6\u7740\u4e00\u4e2a\u201c\u80cc\u5305\u201d\u5230\u5904\u8d70\u800c\u72b9\u8c6b\u3002\u4ece\u4e8b\u4e34\u5e8a\u7814\u7a76\u7684\u540c\u4e8b\u548c\u6211\u63d0\u51fa\u7684\u4e00\u4e2a\u53cd\u9a73\u7406\u7531\u662f\uff0c\u8fd9\u4e2a\u88c5\u7f6e\u7684\u5c3a\u5bf8\u5b9e\u9645\u4e0a\u66f4\u50cf\u662f\u4e00\u4e2a\u201c\u8170\u5305\u201d\uff0c\u5982\u679c\u5907\u9009\u9009\u9879\u53ea\u5269\u4e0b\u6b7b\u4ea1\uff0c\u90a3\u4e48\u60a3\u8005\u4f1a\u6b23\u7136\u63a5\u53d7\u8fd9\u4e2a\u201c\u8170\u5305\u201d\u5e26\u6765\u7684\u6682\u65f6\u4e0d\u4fbf\u3002<\/p>\n<\/blockquote>\n\n\n\n<p>\u8d1d\u6797\u59a5\u7684\u6545\u4e8b\u3002\u7597\u6548\u662f\u7b2c\u4e00\u4f4d\u7684\uff0c\u6bd2\u6027\u662f\u7b2c\u4e8c\u4f4d\u7684\uff0c\u5f88\u9ad8\u5174\u770b\u5230\u4e8c\u4ee3\u7684\u4f4e\u6bd2\u6027\u4ea7\u54c1\u8fdb\u5c55\u4e0d\u9519\u3002<\/p>\n\n\n\n<blockquote 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